Jo, Beom-Geun Park, No-June Kim, Su-Nam Jegal, Jonghwan Choi, Sangho Lee, Sang Woo Yi, Li Wan Lee, Seoung Rak Kim, Ki Hyun Yang, Min Hye 2024-01-19T21:02:52Z 2024-01-19T21:02:52Z 2022-01-25 2019-01 2046-2069 https://pubs.kist.re.kr/handle/201004/120505 The aim of this study was to isolate maltol derivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltol in a 2,4-dinitrochlorobenzene (DNCB)-sensitized mouse model of AD. A novel compound, maltol 3-O-(4'-O-cis-p-coumaroyl)-beta-D-glucoside (named isosoyamaloside I), and two known maltol derivatives (maltol and soyamaloside I) were isolated from S. chamaejasme using chromatographic methods. Dermal application of maltol to DNCB-sensitized AD mice reduced erythema, pruritus, and lichenification scores. Histopathological examinations revealed significant decline in mast cell infiltration in maltol-treated AD mice. In addition, maltol accelerated skin barrier recovery by reducing TEWL and skin pH and increasing skin hydration. Maltol was also found to suppress atopy-induced IL-4 and IgE elevations in serum, which are known to be essential for the development of atopy. The results of this study show that maltol is a potential therapeutic candidate for the treatment of AD-related skin diseases. English ROYAL SOC CHEMISTRY Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice Article 10.1039/c8ra09743g 1 RSC ADVANCES, v.9, no.4, pp.2125 - 2132 RSC ADVANCES 9 4 2125 2132 N scie scopus 000457783900042 2-s2.0-85060288417 Chemistry, Multidisciplinary Chemistry Article DERMATITIS EXPRESSION CYTOKINES MODULATION TACROLIMUS DISEASE BARRIER DRUG