Lee, Kyungwoo Kwon, Yejin Hwang, Jangsun Choi, Yonghyun Kim, Kyobum Koo, Hyung-Jun Seo, Youngmin Jeon, Hojeong Choi, Jonghoon 2024-01-19T21:03:27Z 2024-01-19T21:03:27Z 2021-09-04 2019-01 https://pubs.kist.re.kr/handle/201004/120537 beta-Glucan, a polysaccharide biopolymer, is one of the constituents of cell walls of microorganisms, basidiomycetes, and plants. It has pathogen-associated molecular patterns, recognizing specific immune cell receptors and can induce innate immunity and control acquired immunity. beta-Glucan has properties of biocompatibility, biodegradability, high stability, and low toxicity; therefore, it can be used as a drug-delivery system and therapeutic target. Taking into account the advantages of beta-glucan, we designed porous, hollow beta-glucan microparticles (YGlu) with doxorubicin (DOX), an anticancer drug. We confirmed the successful loading of the drugs in YGlu by chitosan and alginate electrostatic attraction (Mat) through scanning electron microscopy, UV-vis spectroscopy, and Fourier transform infrared spectrometry. We also examined the cytotoxicity and efficiency of YGlu/Mat/DOX in MDA-MB-231 cells, HUVEC cells, and human peripheral blood mononuclear cells (PBMCs). In addition, we investigated the effects of YGlu on the secretion of cytokines in PBMCs. These results suggest that the YGlu/Mat/DOX may be utilized as a promising platform for drug delivery. English ACS Publications Synthesis and Functionalization of beta-Glucan Particles for the Effective Delivery of Doxorubicin Molecules Article 10.1021/acsomega.8b02712 1 ACS Omega, v.4, no.1, pp.668 - 674 ACS Omega 4 1 668 674 Y scie scopus 000460214700072 2-s2.0-85059799671 Chemistry, Multidisciplinary Chemistry Article YEAST PROTEIN NANOPARTICLES