Clayton, Aled Buschmann, Dominik Byrd, J. Brian Carter, David R. F. Cheng, Lesley Compton, Carolyn Daaboul, George Devitt, Andrew Manuel Falcon-Perez, Juan Gardiner, Chris Gustafson, Dakota Harrison, Paul Helmbrecht, Clemens Hendrix, An Hill, Andrew Hoffman, Andrew Jones, Jennifer C. Kalluri, Raghu Kang, Ji Yoon Kirchner, Benedikt Lasser, Cecilia Lawson, Charlotte Lenassi, Metka Levin, Carina Llorente, Alicia Martens-Uzunova, Elena S. Moeller, Andreas Musante, Luca Ochiya, Takahiro Pink, Ryan C. Tahara, Hidetoshi Wauben, Marca H. M. Webber, Jason P. Welsh, Joshua A. Witwer, Kenneth W. Yin, Hang Nieuwland, Rienk 2024-01-19T21:04:37Z 2024-01-19T21:04:37Z 2022-01-25 2018-12 2001-3078 https://pubs.kist.re.kr/handle/201004/120601 This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers. English Co-Action Publishing Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017 Article 10.1080/20013078.2018.1473707 1 Journal of Extracellular Vesicles, v.7, no.1 Journal of Extracellular Vesicles 7 1 Y scie scopus 000432550100001 2-s2.0-85047262302 Cell Biology Cell Biology Article CIRCULATING MICROPARTICLES CANCER CHALLENGES METABOLOME extracellular vesicles exosomes cancer serum plasma urine Biomarkers