Kang, Seounghun Hong, Yu Lim Ku, Bon-Cheol Lee, Seunghyun Ryu, Seongwoo Min, Dal-Hee Jang, Hongje Kim, Young-Kwan 2024-01-19T21:30:40Z 2024-01-19T21:30:40Z 2021-09-05 2018-11-23 0957-4484 https://pubs.kist.re.kr/handle/201004/120668 A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities. English IOP PUBLISHING LTD DRUG-DELIVERY GOLD NANOPARTICLES CELLS REDUCTION ANTICOAGULANT INDUCTION APOPTOSIS MOLECULE Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy Article 10.1088/1361-6528/aadfa5 1 NANOTECHNOLOGY, v.29, no.47 NANOTECHNOLOGY 29 47 scie scopus 000445953400002 2-s2.0-85054534896 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Science & Technology - Other Topics Materials Science Physics Article DRUG-DELIVERY GOLD NANOPARTICLES CELLS REDUCTION ANTICOAGULANT INDUCTION APOPTOSIS MOLECULE fucoidan graphene oxide reduction surface functionalization cancer therapy