Gil, Yeong-Gyu Kang, Seounghun Chae, Ari Kim, Young-Kwan Min, Dal-Hee Jang, Hongje 2024-01-19T21:30:54Z 2024-01-19T21:30:54Z 2021-09-05 2018-11-14 2040-3364 https://pubs.kist.re.kr/handle/201004/120680 Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom (Inonotus obliquus) extract, which has anticancer and antibacterial activities. In the present study, we synthesized anisotropic porous Pd nanostructures with ultraviolet-visible-near infrared whole wavelength region absorption using chaga extract concentration-dependent reductant-mediated synthesis. The porous Pd nanoparticles exhibited a surface chaga extract-derived anticancer effect, controlled delivery of doxorubicin through electrostatic interaction, and a photothermal conversion effect under 808 nm laser irradiation. The combined application of the three cancer treatment approaches clearly demonstrated the feasibility of synergistic tri-modal therapy. The present platform using Pd, which is a key constituent element of nanocatalysts but is not commonly used in biological applications, suggests numerous applications utilizing Pd nanostructures, as well as the potential development of new cancer therapies. English ROYAL SOC CHEMISTRY SILVER NANOPARTICLES MEDICINAL MUSHROOM INONOTUS ANTIOXIDANT BIOSYNTHESIS Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment Article 10.1039/c8nr07172a 1 NANOSCALE, v.10, no.42, pp.19810 - 19817 NANOSCALE 10 42 19810 19817 scie scopus 000449699400015 2-s2.0-85055790379 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Chemistry Science & Technology - Other Topics Materials Science Physics Article SILVER NANOPARTICLES MEDICINAL MUSHROOM INONOTUS ANTIOXIDANT BIOSYNTHESIS Pd nanoparticles Chaga therapeutics