Jalani, Hitesh B. Mali, Jyotirling R. Park, Hyejun Lee, Jae Kyun Lee, Kiho Lee, Kyeong Choi, Yongseok 2024-01-19T21:31:13Z 2024-01-19T21:31:13Z 2021-09-05 2018-11-05 1615-4150 https://pubs.kist.re.kr/handle/201004/120698 An iodine-promoted one-pot synthesis of functionally diverse and highly substituted 4-aminopyrroles directly from aryl methyl ketones, arylamines, and enamines was developed. The reaction involves in-situ oxidation of aryl methyl ketone to glyoxal, subsequent imine formation by aniline, followed by nucleophilic addition of enamine, and cyclization to afford highly substituted 4-aminopyrroles. This reaction involved the formation of two C-N bonds and one C-C bond by a formal [1+1+3] annulation approach. The present method provides an interesting framework of two 4-aminopyrrole units directly attached to a biphenyl core by the reaction of 4,4 '-diacyl biphenyl, amine, and enamine groups. This Hantzsch-type one-pot reaction provides diverse 4-aminopyrroles, which could be useful in medicinal/material chemistry. English WILEY-V C H VERLAG GMBH EFFICIENT SYNTHESIS DOMINO REACTION FUSED PYRROLES PYRIMIDINES DERIVATIVES ALKALOIDS OXIDATION ANILINES Iodine-Promoted One-pot Synthesis of Highly Substituted 4-Aminopyrroles and Bis-4-aminopyrrole from Aryl Methyl Ketones, Arylamines, and Enamines Article 10.1002/adsc.201800899 1 ADVANCED SYNTHESIS & CATALYSIS, v.360, no.21, pp.4073 - 4079 ADVANCED SYNTHESIS & CATALYSIS 360 21 4073 4079 scie scopus 000449688000008 2-s2.0-85053623083 Chemistry, Applied Chemistry, Organic Chemistry Article EFFICIENT SYNTHESIS DOMINO REACTION FUSED PYRROLES PYRIMIDINES DERIVATIVES ALKALOIDS OXIDATION ANILINES 4-Aminopyrroles Kornblum oxidation Enamines Hantzsch-type one-pot approach