Wang, Sun Young Kim, Hyosuk Kwak, Gijung Yoon, Hong Yeol Jo, Sung Duk Lee, Ji Eun Cho, Daeho Kwon, Ick Chan Kim, Sun Hwa 2024-01-19T21:31:46Z 2024-01-19T21:31:46Z 2021-09-05 2018-11 2198-3844 https://pubs.kist.re.kr/handle/201004/120728 In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide. The HA hydrogels are grafted with the REG peptide, a functional derivative of erythroid differentiation regulator1, displaying potent cell motility-stimulating ability, thus sustainably releasing physiologically active peptides for a prolonged period. Combined with the traditional wound healing benefits of HA, the HA hydrogel embedded REG (REG-HAgel) accelerates re-epithelialization in skin wound healing, particularly by promoting migration of fibroblasts, keratinocytes, and endothelial cells. REG-HAgels improve not only rate, but quality of wound healing with higher collagen deposition and more microvascular formation while being nontoxic. The peptide-grafted HA hydrogel system can be considered as a promising new wound dressing formulation strategy for the treatment of different types of wounds with combinations of various natural and synthetic WHPs. English WILEY HYALURONIC-ACID HYDROGELS DEGRADATION DELIVERY RELEASE SYSTEMS Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management Article 10.1002/advs.201800852 1 ADVANCED SCIENCE, v.5, no.11 ADVANCED SCIENCE 5 11 scie scopus 000451173200016 2-s2.0-85053679980 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article HYALURONIC-ACID HYDROGELS DEGRADATION DELIVERY RELEASE SYSTEMS bioorthogonal copper free click chemistry peptide-grafted hyaluronic acid hydrogels would healing peptides wound repair