Kim, Semin Jang, Yohan Jang, Minsu Lim, Ahyoun Hardy, John G. Park, Hyun S. Lee, Jae Young 2024-01-19T21:32:54Z 2024-01-19T21:32:54Z 2021-09-04 2018-10-15 1742-7061 https://pubs.kist.re.kr/handle/201004/120790 Electrically conductive polypyrrole (PPy) is an intriguing biomaterial capable of efficient electrical interactions with biological systems. Especially, biomimetic PPy-based biomaterials incorporating biomolecules, such as hyaluronic acid (HA), can impart the characteristic biological interactions with living cells/tissues to the conductive biomaterials. Here we report the effects of the molecular weight (MW) of HA on PPy-based biomaterials. We utilized HA of a wide range of MW (35 x 10(3) Da-3 x 10(6) Da) as dopants during the electrochemical production of PPy/HA films and their characterization of materials and cellular interactions. With increases in the MWs of HA dopants, PPy/HA exhibited more hydrophilic, higher electrochemical activity and lower impedance. In vitro studies revealed that PPy films doped with low MW HA were supportive to cell adhesion and growth, while PPy films doped with high MW HA were resistant to cell attachment. Subcutaneous implantation of the PPy/HA films for 4 weeks revealed that all the PPy/HA films were tissue compatible. We successfully demonstrate the importance of HA dopant MWs in modulating the chemical and electrical properties of the materials and cellular responses to the materials. Such materials have potential for various biomedical applications, including as tissue engineering scaffolds and as electrodes for neural recording and neuromodulation. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD POLYMER HYDROGEL NERVE GROWTH SURFACE BIOMATERIALS SOFT DOPANTS Versatile biomimetic conductive polypyrrole films doped with hyaluronic acid of different molecular weights Article 10.1016/j.actbio.2018.09.035 1 ACTA BIOMATERIALIA, v.80, pp.258 - 268 ACTA BIOMATERIALIA 80 258 268 scie scopus 000449133400021 2-s2.0-85054395685 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLYMER HYDROGEL NERVE GROWTH SURFACE BIOMATERIALS SOFT DOPANTS Conductive polymer Hyaluronic acid Molecular weight Cellular interactions Bioelectrodes