Abdel-Maksoud, Mohammed S. El-Gamal, Mohammed I. El-Din, Mahmoud M. Gamal Choi, Yunji Choi, Jungseung Shin, Ji-Sun Kang, Shin-Young Yoo, Kyung Ho Lee, Kyung-Tae Baek, Daejin Oh, Chang-Hyun 2024-01-19T21:33:36Z 2024-01-19T21:33:36Z 2021-09-05 2018-10 1420-3049 https://pubs.kist.re.kr/handle/201004/120827 This article describes the design, synthesis, and in vitro anti-inflammatory screening of new triarylpyrazole derivatives. A total of 34 new compounds were synthesized containing a terminal arylsulfonamide moiety and a different linker between the sulfonamide and pyridine ring at position 4 of the pyrazole ring. All the target compounds were tested for both cytotoxicity and nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Compounds 1b, 1d, 1g, 2a, and 2c showed the highest NO inhibition percentages and the lowest cytotoxic effect. The most potent derivatives were tested for their ability to inhibit prostaglandin E-2 (PGE(2)) in LPS-induced RAW 264.7 macrophages. The IC50 for nitric oxide inhibition, PGE(2) inhibition, and cell viability were determined. In addition, 1b, 1d, 1g, 2a, and 2c were tested for their inhibitory effect on LPS-induced inducible nitric oxide synthase (iNOS) and Cyclooxygenase 2 (COX-2) protein expression as well as iNOS enzymatic activity. English MDPI ANTIPROLIFERATIVE ACTIVITY ANTIINFLAMMATORY ACTIVITIES DESIGN INFLAMMATION PYRAZOLE CYCLOOXYGENASE-2 CHEMOKINES CANCER AGENTS RISK Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE(2) and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages Article 10.3390/molecules23102556 1 MOLECULES, v.23, no.10 MOLECULES 23 10 scie scopus 000451201400152 2-s2.0-85054470458 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article ANTIPROLIFERATIVE ACTIVITY ANTIINFLAMMATORY ACTIVITIES DESIGN INFLAMMATION PYRAZOLE CYCLOOXYGENASE-2 CHEMOKINES CANCER AGENTS RISK anti-inflammatory inducible nitric oxide synthase (iNOS) nitric oxide prostaglandine E-2 triarylpyrazole