Park, Jun Yeon Lee, Dong-Soo Kim, Chang-Eop Shin, Myoung-Sook Seo, Chang-Seob Shin, Hyeun-Kyoo Hwang, Gwi Seo An, Jun Min Kim, Su-Nam Kang, Ki Sung 2024-01-19T21:34:18Z 2024-01-19T21:34:18Z 2021-09-04 2018-10 1226-8453 https://pubs.kist.re.kr/handle/201004/120866 Background: Fermented black ginseng (FBG) is produced through several cycles of steam treatment of raw ginseng, at which point its color turns black. During this process, the original ginsenoside components of raw ginseng (e.g., Re, Rg1, Rb1, Rc, and Rb2) are altered, and less-polar ginsenosides are generated (e.g., Rg3, Rg5, Rk1, and Rh4). The aim of this study was to determine the effect of FBG on wound healing. Methods: The effects of FBG on tube formation and on scratch wound healing were measured using human umbilical vein endothelial cells (HUVECs) and HaCaT cells, respectively. Protein phosphorylation of mitogen-activated protein kinase was evaluated via Western blotting. Finally, the wound-healing effects of FBG were assessed using an experimental cutaneous wounds model in mice. Results and Conclusion: The results showed that FBG enhanced the tube formation in HUVECs and migration in HaCaT cells. Western blot analysis revealed that FBG stimulated the phosphorylation of p38 and extracellular signal-regulated kinase in HaCaT cells. Moreover, mice treated with 25 mg/mL of FBG exhibited faster wound closure than the control mice did in the experimental cutaneous wounds model in mice. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. English KOREAN SOC GINSENG FIBROBLAST-GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IN-VITRO PANAX-GINSENG EXTRACELLULAR-MATRIX PROLIFERATION INFLAMMATION MODULATION MECHANISMS MIGRATION Effects of fermented black ginseng on wound healing mediated by angiogenesis through the mitogen-activated protein kinase pathway in human umbilical vein endothelial cells Article 10.1016/j.jgr.2017.07.006 1 JOURNAL OF GINSENG RESEARCH, v.42, no.4, pp.524 - 531 JOURNAL OF GINSENG RESEARCH 42 4 524 531 scie scopus kci ART002408856 000447034200015 2-s2.0-85028359211 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article FIBROBLAST-GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IN-VITRO PANAX-GINSENG EXTRACELLULAR-MATRIX PROLIFERATION INFLAMMATION MODULATION MECHANISMS MIGRATION ginseng human umbilical vein endothelial cells vascular endothelial growth factor wound healing