Lee, Seung-Chul Heo, Jeongyun Woo, Hee Chul Lee, Ji-Ah Seo, Young Hun Lee, Chang-Lyoul Kim, Sehoon Kwon, O-Pil 2024-01-19T22:00:21Z 2024-01-19T22:00:21Z 2021-09-03 2018-09-18 0947-6539 https://pubs.kist.re.kr/handle/201004/120908 Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent pi-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push-pull type pi-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed. English WILEY-V C H VERLAG GMBH INTRAMOLECULAR CHARGE-TRANSFER THIOFLAVIN-T CELL-MEMBRANE IMAGING VISCOSITY LIPID-MEMBRANES EXCITED-STATES SHEAR-STRESS LIVE CELLS PROBE SENSITIVITY Fluorescent Molecular Rotors for Viscosity Sensors Article 10.1002/chem.201801389 1 CHEMISTRY-A EUROPEAN JOURNAL, v.24, no.52, pp.13706 - 13718 CHEMISTRY-A EUROPEAN JOURNAL 24 52 13706 13718 scie scopus 000445447300003 2-s2.0-85053875860 Chemistry, Multidisciplinary Chemistry Review INTRAMOLECULAR CHARGE-TRANSFER THIOFLAVIN-T CELL-MEMBRANE IMAGING VISCOSITY LIPID-MEMBRANES EXCITED-STATES SHEAR-STRESS LIVE CELLS PROBE SENSITIVITY fluorescence dynamics fluorescent molecular rotors microviscosity molecular rotors viscosity sensors