Jegal, Jonghwan Park, No-June Jo, Beom-Geun Bong, Sim-Kyu Jegal, Hyun Yang, Min Hye Kim, Su-Nam 2024-01-19T22:01:56Z 2024-01-19T22:01:56Z 2021-09-03 2018-09 2072-6643 https://pubs.kist.re.kr/handle/201004/120990 Naturally occurring saponins have been reported to have anti-inflammatory and immunomodulatory effects. However, the effects of gracillin, a main saponin component of Dioscorea quinqueloba (D. quinqueloba), on atopic dermatitis (AD), have not been previously studied. The aim of this study was to determine whether gracillin isolated from D. quinqueloba has an anti-AD effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Topical co-treatment of gracillin and DNCB for two weeks markedly reduced symptoms typical of AD (redness, itching, swelling and skin lichenification), decreased transepidermal water loss (TEWL) and increased skin hydration. In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice. Our results suggest gracillin is a potential candidate for the prevention and treatment of AD and other inflammatory skin disorders. English MDPI BARRIER DYSFUNCTION INTERFERON-GAMMA DERMATITIS SAPONINS PIMECROLIMUS ENHANCEMENT TACROLIMUS DISEASE DRY Anti-Atopic Properties of Gracillin Isolated from Dioscorea quinqueloba on 2,4-Dinitrochlorobenzene-Induced Skin Lesions in Mice Article 10.3390/nu10091205 1 NUTRIENTS, v.10, no.9 NUTRIENTS 10 9 scie scopus 000448659900078 2-s2.0-85052963184 Nutrition & Dietetics Nutrition & Dietetics Article BARRIER DYSFUNCTION INTERFERON-GAMMA DERMATITIS SAPONINS PIMECROLIMUS ENHANCEMENT TACROLIMUS DISEASE DRY gracillin Dioscorea quinqueloba 2 4-dinitrochlorobenzene atopic dermatitis skin barrier recovery interleukin 4