Maccioni, Paola Fara, Federica Gessa, Gian Luigi Carai, Mauro A. M. Chin, Young-Won Lee, Jung Hwan Kwon, Hak Cheol Colombo, Giancarlo 2024-01-19T22:02:49Z 2024-01-19T22:02:49Z 2021-09-03 2018-08-13 1664-0640 https://pubs.kist.re.kr/handle/201004/121039 Recent lines of experimental evidence have indicated that saikosaponin A (SSA)-a bioactive ingredient of the medicinal plant, Bupleurum falcatum L.-potently and effectively reduced operant self-administration of chocolate and reinstatement of chocolate-seeking behavior in rats. The present study was designed to assess whether the protective properties of SSA on addictive-like, food-related behaviors generalize to a rat model of overeating of palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-h chow-feeding session was followed by a 1-h availability of highly palatable, calorie-rich Danish butter cookies or Oreo chocolate cookies. Even though fed, rats consumed large amounts of cookies; intake of calories from cookies (consumed in 1 h) was even larger than that of calories from chow (consumed in 3 h). SSA (0, 0.25, 0.5, and 1 mg/kg, i.p.) was administered 10min before cookie presentation. Treatment with SSA resulted in a dose-related decrease in intake of both butter and chocolate cookies. Administration of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant (0, 0.3, 1, and 3 mg/kg, i.p.; tested as reference compound), produced a similar reduction in intake of butter cookies. These results (a) contribute to the set-up and validation of a rat model of overeating, characterized by the intake of large amounts of unnecessary calories and (b) provide an additional piece of evidence to the anorectic profile of SSA in rats. English FRONTIERS MEDIA SA CB1 RECEPTOR ANTAGONIST GABA(B) RECEPTOR POTENTIAL USE RIMONABANT BACLOFEN ADDICTION BEHAVIOR OBESITY PLASMA MICE Reducing Effect of Saikosaponin A, an Active Ingredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating Article 10.3389/fpsyt.2018.00369 1 FRONTIERS IN PSYCHIATRY, v.9 FRONTIERS IN PSYCHIATRY 9 scie ssci scopus 000441411600001 2-s2.0-85052214681 Psychiatry Psychiatry Article CB1 RECEPTOR ANTAGONIST GABA(B) RECEPTOR POTENTIAL USE RIMONABANT BACLOFEN ADDICTION BEHAVIOR OBESITY PLASMA MICE saikosaponin A Bupleurum falcatum L. rimonabant overeating palatable food rats