Lee, Jung Eun Kim, Myung Goo Jang, Yeon Lim Lee, Min Sang Kim, Nak Won Yin, Yue Lee, Jong Han Lim, Su Yeon Park, Ji Won Kim, Jaeyun Lee, Doo Sung Kim, Sun Hwa Jeong, Ji Hoon 2024-01-19T22:04:38Z 2024-01-19T22:04:38Z 2021-09-03 2018-07-25 1071-7544 https://pubs.kist.re.kr/handle/201004/121136 Paclitaxel (PTX) is used as a major antitumor agent for the treatment of recurrent and metastatic breast cancer. For the clinical application of PTX, it needs to be dissolved in an oil/detergent-based solvent due to its poor solubility in an aqueous medium. However, the formulation often causes undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose-dependent antitumor effect. Herein, we introduce a facile and oil-free method to prepare albumin-based PTX nanoparticles for efficient systemic cancer therapy using a conjugate of human serum albumin (HSA) and poly(ethyleneglycol) (PEG). PTX were efficiently incorporated in the self-assembled HSA-PEG nanoparticles (HSA-PEG/PTX) using a simple film casting and re-hydration procedure without additional processes such as application of high pressure/shear or chemical crosslinking. The spherical HSA-PEG nanoparticle with a hydrodynamic diameter of ca. 280 nm mediates efficient cellular delivery, leading to comparable or even higher cytotoxicity in various breast cancer cells than that of the commercially available Abraxane((R)). When systemically administered in a mouse xenograft model for human breast cancer, the HSA-PEG-based nanoparticle formulation exhibited an extended systemic circulation for more than 96 h and enhanced intratumoral accumulation, resulting in a remarkable anticancer effect and prolonged survival of the animals. English TAYLOR & FRANCIS LTD CARGO LOADING CAPACITY CREMOPHOR-FREE BOUND PACLITAXEL MACROMOLECULAR THERAPEUTICS POLYETHYLENE-GLYCOL ANTITUMOR-ACTIVITY ABI-007 STABILITY CARRIERS AGENT Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging Article 10.1080/10717544.2018.1489430 1 DRUG DELIVERY, v.25, no.1, pp.1570 - 1578 DRUG DELIVERY 25 1 1570 1578 scie scopus 000439973400002 2-s2.0-85055734381 Pharmacology & Pharmacy Pharmacology & Pharmacy Article CARGO LOADING CAPACITY CREMOPHOR-FREE BOUND PACLITAXEL MACROMOLECULAR THERAPEUTICS POLYETHYLENE-GLYCOL ANTITUMOR-ACTIVITY ABI-007 STABILITY CARRIERS AGENT Drug dissolution oil-free formulation human serum albumin self-assembled nanoparticle systemic cancer therapy