El-Gamal, Mohammed, I Al-Ameen, Shahad K. Al-Koumi, Dania M. Hamad, Mawadda G. Jalal, Nouran A. Oh, Chang-Hyun 2024-01-19T22:04:57Z 2024-01-19T22:04:57Z 2022-01-10 2018-07-12 0022-2623 https://pubs.kist.re.kr/handle/201004/121152 Colony stimulation factor-1 receptor (CSF-1R), which is also known as FMS kinase, plays an important role in initiating inflammatory, cancer, and bone disorders when it is overstimulated by its ligand, CSF-1. Innate immunity, as well as macrophage differentiation and survival, are regulated by the stimulation of the CSF-1R. Another ligand, interlukin-34 (IL-34), was recently reported to activate the CSF-1R receptor in a different manner. The relationship between CSF-1R and microglia has been reviewed. Both CSF-1 antibodies and small molecule CSF-1R kinase inhibitors have now been tested in animal models and in humans. In this Perspective, we discuss the role of CSF-1 and IL-34 in producing cancer, bone disorders, and inflammation. We also review the newly discovered and improved small molecule kinase inhibitors and monoclonal antibodies that have shown potent activity toward CSF-1R, reported from 2012 until 2017. English AMER CHEMICAL SOC TUMOR-ASSOCIATED MACROPHAGES MONOCLONAL-ANTIBODY INFILTRATING MACROPHAGES RHEUMATOID-ARTHRITIS SPECIES-SPECIFICITY TYROSINE KINASES POTENT CLASS C-FMS CANCER CELL Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors Article 10.1021/acs.jmedchem.7b00873 1 JOURNAL OF MEDICINAL CHEMISTRY, v.61, no.13, pp.5450 - 5466 JOURNAL OF MEDICINAL CHEMISTRY 61 13 5450 5466 scie scopus 000439006100002 2-s2.0-85046648355 Chemistry, Medicinal Pharmacology & Pharmacy Article TUMOR-ASSOCIATED MACROPHAGES MONOCLONAL-ANTIBODY INFILTRATING MACROPHAGES RHEUMATOID-ARTHRITIS SPECIES-SPECIFICITY TYROSINE KINASES POTENT CLASS C-FMS CANCER CELL CSF-1 kinase Breast Cancer Interleukin-34