Choi, HaeRi Park, Jin-Soo Kim, Kyu-Min Kim, MinSun Ko, Kwang-Wook Hyun, Chang-Gu Ahn, Joong Woo Seo, Joo-Hyun Kim, Seung-Young 2024-01-19T22:31:13Z 2024-01-19T22:31:13Z 2021-09-03 2018-07 1226-086X https://pubs.kist.re.kr/handle/201004/121207 In this study, we report Bio-renovation, which is a method to biologically derivatize natural compounds to make drug candidate library. In this method, microorganisms produce various derivatives of natural compounds, thereby converting natural compounds into novel bioactive candidates. Five derivatives of genistein were synthesized by Bio-renovation using Bacillus amyloliquefaciens KCTC 13588. Among the genistein derivatives, 4'-O-isopropyl genistein showed antimicrobial activity against eight strains including methicillin resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) with MIC and MBC values of 8-128 mu g/ml. We could find that 4'-O-isopropyl genistein has higher antimicrobial activity than genistein to gram-positive bacteria. (C) 2018 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry. English 한국공업화학회 Enhancing the antimicrobial effect of genistein by biotransformation in microbial system Article 10.1016/j.jiec.2018.02.023 1 Journal of Industrial and Engineering Chemistry, v.63, pp.255 - 261 Journal of Industrial and Engineering Chemistry 63 255 261 N scie scopus kci ART002371209 000434001000030 2-s2.0-85042348399 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article NATURAL-PRODUCTS FLAVONOIDS ISOFLAVONES 7-O-PHOSPHATE BIOCATALYSIS SOYBEANS WOMEN Derivatization Chemical library Biotransformation Genistein Antimicrobial activity