Ko, Jeong-Hyeon Nam, Dongwoo Um, Jae-Young Jung, Sang Hoon Sethi, Gautam Ahn, Kwang Seok 2024-01-19T22:31:40Z 2024-01-19T22:31:40Z 2021-08-31 2018-07 1420-3049 https://pubs.kist.re.kr/handle/201004/121231 Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. However, there is no available evidence that BGM has an inhibitory effect on cancer metastasis, specifically on the epithelial-to-mesenchymal transition (EMT) process in the malignant cells. Here we aimed to evaluate the antimetastatic potential of BGM in human lung adenocarcinoma cells. Our results demonstrate that BGM can block EMT, and observed inhibition was accompanied by downregulation of fibronectin, vimentin, N-cadherin, twist and snail expression, and upregulation of occludin and E-cadherin. Interestingly, transforming growth factor-beta (TGF-beta)-induced upregulation of fibronectin, vimentin, N-cadherin, twist and snail, and downregulation of occludin and E-cadherin, were abrogated by BGM treatment. Moreover, the treatment of BGM repressed TGF-beta-induced cell invasive potential. BGM treatment also inhibited multiple oncogenic cascades such as PI3K/Akt/mTOR. Overall, the results demonstrate the potential antimetastatic activity of BGM against lung cancer cells. English MDPI MOUSE PROSTATE MODEL TUMOR-METASTASIS INHIBITS GROWTH TRANSGENIC ADENOCARCINOMA APOPTOSIS PATHWAY PROGRESSION ACTIVATION EXPRESSION CARCINOMA Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition Article 10.3390/molecules23071601 1 MOLECULES, v.23, no.7 MOLECULES 23 7 scie scopus 000445301800104 2-s2.0-85049483025 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article MOUSE PROSTATE MODEL TUMOR-METASTASIS INHIBITS GROWTH TRANSGENIC ADENOCARCINOMA APOPTOSIS PATHWAY PROGRESSION ACTIVATION EXPRESSION CARCINOMA bergamottin EMT metastasis lung cancer