Jun, Indong Kim, Kyeongsoo Chung, Yong-Woo Shin, Hyeok Jun Han, Hyung-Seop Edwards, James R. Ok, Myoung-Ryul Kim, Yu-Chan Seok, Hyun-Kwang Shin, Heungsoo Jeon, Hojeong 2024-01-19T22:33:15Z 2024-01-19T22:33:15Z 2021-09-03 2018-06 1549-3296 https://pubs.kist.re.kr/handle/201004/121311 Biological responses on biomaterials occur either on their surface or at the interface. Therefore, surface characterization is an essential step in the fabrication of ideal biomaterials for achieving effective control of the interaction between the material surface and the biological environment. Herein, we applied femtosecond laser ablation on electrospun fibrous scaffolds to fabricate various hierarchical patterns with a focus on the alignment of cells. We investigated the simultaneously stimulated response of cardiomyoblasts based on multiple topographical cues, including scales, oriented directions, and spatial arrangements, in the fibrous scaffolds. Our results demonstrated a synergistic effect on cell behaviors of one or more structural arrangements in a homogeneous orientation, whereas antagonistic effects were observed for cells arranged on a surface with heterogeneous directions. Taken together, these results indicate that our hierarchically patterned fibrous scaffolds may be useful tools for understanding the cellular behavior on fibrous scaffolds used to mimic an extracellular matrix-like environment. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1732-1742, 2018. English John Wiley & Sons Inc. Effect of spatial arrangement and structure of hierarchically patterned fibrous scaffolds generated by a femtosecond laser on cardiomyoblast behavior Article 10.1002/jbm.a.36374 1 Journal of Biomedical Materials Research - Part A, v.106, no.6, pp.1732 - 1742 Journal of Biomedical Materials Research - Part A 106 6 1732 1742 N scie scopus 000431004500026 2-s2.0-85044341395 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article TOPOGRAPHICAL FEATURES CELL-ADHESION ELECTROSPUN CARDIOMYOCYTES REGENERATION MIGRATION BIOMATERIALS NANOFIBERS PLATFORMS GUIDANCE ECM topographical cue cardiomyoblasts femtosecond laser electrospinning