Chae, Sieun Kim, Dahee Lee, Kyung-jin Lee, Dasol Kim, Young-O Jung, Yong Chae Dal Rhee, Sang Kim, Kwang Rok Lee, Jeong-O Ahn, Sunjoo Koh, Byumseok 2024-01-19T22:33:36Z 2024-01-19T22:33:36Z 2021-09-03 2018-06 2470-1343 https://pubs.kist.re.kr/handle/201004/121330 The topoisomerase I inhibitors SN-38 and camptothecin (CPT) have shown potent anticancer activity, but water insolubility and metabolic instability limits their clinical application. Utilizing carbon nanotubes as a protective shell for water-insoluble SN-38 and CPT while maintaining compatibility with aqueous media via a carboxylic acid-functionalized surface can thus be a strategy to overcome this limitation. Through hydrophobic-hydrophobic interactions, SN-38 and CPT were successfully encapsulated in carboxylic acid functionalized single-walled carbon nanotubes and dispersed in water. The resulting cell proliferation inhibition and drug distribution profile inside the cells suggest that these drug-encapsulated carbon nanotubes can serve as a promising delivery strategy for water-insoluble anticancer drugs. English AMER CHEMICAL SOC MOLECULAR-DYNAMICS RAMAN-SPECTROSCOPY LUNG-CANCER CAMPTOTHECIN RELEASE DRUG SN-38 CELLS LONG MICE Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes Article 10.1021/acsomega.8b00399 1 ACS OMEGA, v.3, no.6, pp.5938 - 5945 ACS OMEGA 3 6 5938 5945 scie scopus 000436340500002 2-s2.0-85047942375 Chemistry, Multidisciplinary Chemistry Article MOLECULAR-DYNAMICS RAMAN-SPECTROSCOPY LUNG-CANCER CAMPTOTHECIN RELEASE DRUG SN-38 CELLS LONG MICE