Kim, Minkyung Jinki Hong Shin, Hyun-Joon 2024-01-19T22:33:37Z 2024-01-19T22:33:37Z 2021-09-03 2018-06 2156-7085 https://pubs.kist.re.kr/handle/201004/121331 We present a new fiber-bundle-based endomicroscopy system to measure the fast cerebral blood flow (CBF) velocity in blood vessels located between the surface and the deep brain of living animals. The CBF velocity is obtained by measuring the displacement of the partially overlapped red blood cell images directly, using double-pulse 532-nm laser illumination. The proposed method could measure CBF in blood vessels with diameters ranging from 4 mu m to 42 mu m and could measure CBF velocities up to 3.2 mu m/ms for different vessel diameters at a depth of 2.1 mm from the brain surface in a living mouse. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement English The Optical Society Double-pulse laser illumination method for measuring fast cerebral blood flow velocities in the deep brain using a fiber-bundle-based endomicroscopy system Article 10.1364/BOE.9.002699 1 Biomedical Optics Express, v.9, no.6, pp.2699 - 2715 Biomedical Optics Express 9 6 2699 2715 N scie scopus 000433954500018 2-s2.0-85048202269 Biochemical Research Methods Optics Radiology, Nuclear Medicine & Medical Imaging Biochemistry & Molecular Biology Optics Radiology, Nuclear Medicine & Medical Imaging Article PARTICLE IMAGE VELOCIMETRY IN-VIVO ALZHEIMERS-DISEASE CAPILLARIES MICROSCOPE PIV MICROCIRCULATION MICROVESSELS STIMULATION METABOLISM fiber optics imaging integrated optics blood monitoring endoscopic imaging fluorescence microscopy