Kim, Young-O Park, Sung-Jun Jung, Byeong Yeon Jang, Hyung-Seok Choi, Seo Keong Kim, Jaehi Kim, Sehoon Jung, Yong Chae Shin, Dong-Sik Lee, Yoon-Sik 2024-01-19T23:00:30Z 2024-01-19T23:00:30Z 2021-09-03 2018-05 2470-1343 https://pubs.kist.re.kr/handle/201004/121412 Here, we describe a rapid and efficient synthetic method of peptide-conjugated perylene diimide (P-PDI) using solid-phase peptide synthesis (SPPS). Due to severe insolubility of perylene dianhydride (PDA) as a starting material of perylene diimide (PDI), PDA was initially conjugated with amino acids to obtain soluble PDI derivatives. Target peptides were synthesized on a 2-chlorotrityl chloride resin using the SPPS method and then conjugated with the amino acid-appended PDI. Various conditions such as loading levels, reaction times and solvents were optimized for introducing the peptides to both sides of the amino acid-appended PDI. The final P-PDI was obtained with a maximum yield of 80% in 12 h. Its singlet oxygen-derived phototoxicity on cells was confirmed, which could be applicable to photodynamic therapy. English AMER CHEMICAL SOC LASER HAIR REMOVAL SINGLET OXYGEN BIOLOGICAL APPLICATIONS CLINICAL USE ND-YAG CANCER PHOTOSENSITIZERS TATTOOS RUBY RGD Solid-Phase Synthesis of Peptide-Conjugated Perylene Diimide Bolaamphiphile and Its Application in Photodynamic Therapy Article 10.1021/acsomega.8b00040 1 ACS OMEGA, v.3, no.5, pp.5896 - 5902 ACS OMEGA 3 5 5896 5902 scie scopus 000434355300131 2-s2.0-85048021538 Chemistry, Multidisciplinary Chemistry Article LASER HAIR REMOVAL SINGLET OXYGEN BIOLOGICAL APPLICATIONS CLINICAL USE ND-YAG CANCER PHOTOSENSITIZERS TATTOOS RUBY RGD peptide