Lee, Dahae Lee, Heesu Kang, Ki Sung Lee, Jae Wook 2024-01-19T23:00:47Z 2024-01-19T23:00:47Z 2021-09-03 2018-05 0253-2964 https://pubs.kist.re.kr/handle/201004/121428 The kidney has various functions, including modulating blood pressure, balancing electrolytes, and controlling blood volume. Among these functions, extracting metabolic waste from blood plays an important role in kidney. 1,2 Additionally, kidney epithelial cells are vulnerable to the toxic effects of various chemical agents and medications. 3,4 Recently, cisplatin, an inorganic platinum-based chemotherapeutic agent, has been used to inhibit solid malignant tumors due to its high therapeutic potential. 5,6 However, continuous exposure to cisplatin can cause various significant side effects, such as bone marrow suppression, peripheral neuropathy, and nephrotoxicity. In particular, a single dose of cisplatin treatment can cause nephrotoxicity among one-third of patients.(7-9) Therefore, it has been suggested to develop medication for cisplatin-induced nephrotoxicity. English 대한화학회 2-Bromo-4,5-Dimethoxy Chalcone Inhibits Cisplatin-induced LLC-PK1 Kidney Cell Death Article 10.1002/bkcs.11454 1 Bulletin of the Korean Chemical Society, v.39, no.5, pp.699 - 702 Bulletin of the Korean Chemical Society 39 5 699 702 N scie scopus kci ART002345475 000431622800022 2-s2.0-85045315288 Chemistry, Multidisciplinary Chemistry Article BIOLOGICAL EVALUATION INDUCED CYTOTOXICITY TYROSINE KINASE AGENTS ANALOGS APOPTOSIS INJURY ISOLIQUIRITIGENIN PATHWAYS DESIGN Chalcone Cisplatin Kidney cells Renoprotection MAPK pathway