Kim, Hong Nam Kim, Jangho 2024-01-19T23:00:51Z 2024-01-19T23:00:51Z 2021-09-03 2018-05 1536-125X https://pubs.kist.re.kr/handle/201004/121432 Since the adaptation of surface topography in the biomedical engineering field, its promising ability in the modulation of cell behaviors and functions has been highlighted by comparing the cell behaviors on patterned and nonpatterned substrates. However, growing evidence indicates that not only the topography itself but also its size can significantly affect the cell behaviors and functions. In this review, the effect of topographical feature size on the biointerface-mediated control of cell behavior is overviewed. The cell behaviors such as migration, differentiation, cell reprogramming, cell phenotype, and transfection, in general, showed two representative trends: biphasic and monotonic as the feature size changed. Based on the observations, we suggest that the sophisticated design of geometrical feature size might be a key regulator on the control of cell behaviors and functions. English IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC MATRIX NANOTOPOGRAPHY STEM-CELLS DIFFERENTIATION ORIENTATION PHENOTYPE SHAPE Effect of Topographical Feature Size on the Trend of Cell Behaviors Article 10.1109/TNANO.2017.2771311 1 IEEE TRANSACTIONS ON NANOTECHNOLOGY, v.17, no.3, pp.377 - 380 IEEE TRANSACTIONS ON NANOTECHNOLOGY 17 3 377 380 scie scopus 000432203200002 2-s2.0-85033704771 Engineering, Electrical & Electronic Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Engineering Science & Technology - Other Topics Materials Science Physics Article MATRIX NANOTOPOGRAPHY STEM-CELLS DIFFERENTIATION ORIENTATION PHENOTYPE SHAPE Nanotopography feature size cell behavior cell function