Seo, Minkoo Kim, Seung Min Woo, Eun Young Han, Ki-Cheol Park, Eun Joo Ko, Seongyeol Choi, Eun Wook Jang, Mihue 2024-01-19T23:02:31Z 2024-01-19T23:02:31Z 2021-09-03 2018-04 1687-966X https://pubs.kist.re.kr/handle/201004/121519 Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo. Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications. English HINDAWI LTD EXTRACELLULAR VESICLES EMERGING ROLE SELF-RENEWAL EXOSOMES PROLIFERATION MICROVESICLES MICRORNA LEUKEMIA APOPTOSIS DELIVERY Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells Article 10.1155/2018/4851949 1 STEM CELLS INTERNATIONAL, v.2018 STEM CELLS INTERNATIONAL 2018 scie scopus 000429638300001 2-s2.0-85056143401 Cell & Tissue Engineering Cell Biology Article EXTRACELLULAR VESICLES EMERGING ROLE SELF-RENEWAL EXOSOMES PROLIFERATION MICROVESICLES MICRORNA LEUKEMIA APOPTOSIS DELIVERY