Kang, Yoon Young Song, Jihyeon Jung, Hee Sun Kwak, Gijung Yu, Gyeonghui Ahn, Joong-Hoon Kim, Sun Hwa Mok, Hyejung 2024-01-19T23:02:47Z 2024-01-19T23:02:47Z 2021-09-03 2018-04 1226-086X https://pubs.kist.re.kr/handle/201004/121534 To examine proper multivalency and type of aptamers in linear nucleic acid-based structures for efficient intracellular uptakes, we designed linear DNA structures with single and dual aptamers targeting guanosine-rich oligonucleotide 100 (AS1411) and mucin 1 (MUC-1). Multivalent linear DNA structures containing dual types of aptamers showed significantly superior cellular internalization. In addition, multivalent aptamer-immobilized DNA-RNA hybrid structures showed excellent tumor accumulation in vivo without liver toxicity and very low nonspecific cytokine induction. Thus, these multivalent nucleic acid based structures with dual types of aptamers can be specifically applied as carriers of therapeutic nucleic acids without inducing noticeable systemic toxicity. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. English 한국공업화학회 Implication of multivalent aptamers in DNA and DNA-RNA hybrid structures for efficient drug delivery in vitro and in vivo Article 10.1016/j.jiec.2017.11.011 1 Journal of Industrial and Engineering Chemistry, v.60, pp.250 - 258 Journal of Industrial and Engineering Chemistry 60 250 258 N scie scopus kci 000428103100021 2-s2.0-85038845658 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article ROLLING CIRCLE AMPLIFICATION CANCER-THERAPY INTRACELLULAR DELIVERY TARGETED DELIVERY THERAPEUTICS CELLS NANOPARTICLES SIRNA PARTICLES ACID Multivalent Aptamer Nucleic acid structures Delivery