Baba, Takashi Otake, Hiroyuki Inoue, Miki Sato, Tetsuya Ishihara, Yasuhiro Moon, Ju-Yeon Tsuchiya, Megumi Miyabayashi, Kanako Ogawa, Hidesato Shima, Yuichi Wang, Lixiang Sato, Ryuichiro Yamazaki, Takeshi Suyama, Mikita Nomura, Masatoshi Choi, Man Ho Ohkawa, Yasuyuki Morohashi, Ken-ichirou 2024-01-19T23:02:48Z 2024-01-19T23:02:48Z 2021-09-03 2018-04 2399-3642 https://pubs.kist.re.kr/handle/201004/121535 Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level. English Nature Publishing Group Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids Article 10.1038/s42003-018-0020-z 1 Communications Biology, v.1, no.1 Communications Biology 1 1 N scopus 000461126500018 2-s2.0-85070966856 Biology Multidisciplinary Sciences Life Sciences & Biomedicine - Other Topics Science & Technology - Other Topics Article HIGH-DENSITY-LIPOPROTEIN ATP-CITRATE-LYASE PROTEIN/STEROIDOGENIC FACTOR-1 TRANSCRIPTIONAL REGULATION PROTEIN CELLS GENE STEROIDOGENESIS METABOLISM PROMOTERS Ad4BP/SF-1 cholesterol steroidogenesis