Lim, Sungsu Kim, Dohee Ju, Shinyeong Shin, Seulgi Cho, Il-joo Park, Sung-Hye Grailhe, Regis Lee, Cheolju Kim, Yun Kyung 2024-01-19T23:03:27Z 2024-01-19T23:03:27Z 2021-09-03 2018-04 1226-3613 https://pubs.kist.re.kr/handle/201004/121571 During aggressive tumor growth and migration, glioblastoma cells secrete diverse molecules and adhesion proteins to the extracellular matrix. Yet, the biochemical effects of the glioblastoma secretome in the brain remain largely unknown. Here we show that soluble CD44 secreted from glioblastoma cells induces neuronal degeneration through the activation of tau pathology in the brain. Glioblastoma-xenograft tissues showed a number of degenerating neurons bearing highly phosphorylated tau. Through a series of secretome-analyses, we identified that soluble CD44 was the responsible protein inducing tau phosphorylation and aggregation (EC50 = 19.1 ng/mL). The treatment of sCD44 to primary hippocampal neurons-induced tau hyperphosphorylation, leading to neuronal degeneration. Also, the injection of sCD44 into the brains of tau transgenic mice induced tau hyper-phosphorylation in hippocampal neurons. Altogether, our data suggest a neurodegenerative role of sCD44 in promoting tau pathology and serving as a molecular link between glioblastoma and neurodegeneration. English 생화학분자생물학회 Glioblastoma-secreted soluble CD44 activates tau pathology in the brain Article 10.1038/s12276-017-0008-7 1 Experimental & Molecular Medicine, v.50, pp.1 - 11 Experimental & Molecular Medicine 50 1 11 N scie scopus kci ART002342538 000429383000003 2-s2.0-85045123853 Biochemistry & Molecular Biology Medicine, Research & Experimental Biochemistry & Molecular Biology Research & Experimental Medicine Article OXIDATIVE STRESS CELL-MIGRATION GLIOMA TUMORS CANCER EPIDEMIOLOGY DEGENERATION MECHANISMS SIGNATURE QUALITY-OF-LIFE 퇴행성 뇌질환 교모세포종 타우인산화 신경퇴행 CD44