Lee, Sullim Park, No-June Bong, Sim-Kyu Jegal, Jonghwan Park, Sang-a Kim, Su-Nam Yang, Min Hye 2024-01-19T23:03:46Z 2024-01-19T23:03:46Z 2021-09-03 2018-03-25 0378-8741 https://pubs.kist.re.kr/handle/201004/121586 Ethnopharmacological relevance: The fruits of Juniperus rigida have been used in Korean traditional medicine for the treatment of inflammatory diseases in humans such as rheumatoid arthritis. Aim of the study: This study aimed to investigate the anti-atopic properties of J. rigida fruit in in vivo murine atopic dermatitis (AD) models. Methods and results: BALB/c mouse ears ad SKH-1 hairless mice stimulated with oxazolone (4 weeks) and DNCB (3 weeks), respectively, were treated with the 1% Juniperus rigida fruit EtOH extract (JFE). The JFE improved AD symptoms in both oxazolone- and DNCB-induced AD mice by accelerating skin barrier recovery function and suppressing the overproduction of serum immunoglobulin E (IgE) and interleukin 4 (IL-4). The JFE was found to contain isoscutellarein-7-O-beta-xylopyranoside, cupressuflavone, podocarpusflavone A, and hinokiflavone as major components based on phytochemical analysis. Eight flavonoids were isolated from JFE, and of those, cupressuflavone and isoscutellarein-7-O-beta-xylopyranoside strongly down-regulated IL-4 expression and P-hexosaminidase release in RBL-2H3 cells. Conclusion: Therapeutic attempts with J. rigida fruit and its active components might be useful in treating AD and related skin inflammatory diseases. English ELSEVIER IRELAND LTD CONTACT HYPERSENSITIVITY STRATUM-CORNEUM HAIRLESS MOUSE IGE SYNTHESIS IN-VITRO SKIN BIFLAVONOIDS CYTOKINES CHILDREN EFFICACY Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice Article 10.1016/j.jep.2017.12.022 1 JOURNAL OF ETHNOPHARMACOLOGY, v.214, pp.160 - 167 JOURNAL OF ETHNOPHARMACOLOGY 214 160 167 scie scopus 000426230900019 2-s2.0-85038405073 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article CONTACT HYPERSENSITIVITY STRATUM-CORNEUM HAIRLESS MOUSE IGE SYNTHESIS IN-VITRO SKIN BIFLAVONOIDS CYTOKINES CHILDREN EFFICACY Juniperus rigida fruit Atopic dermatitis Skin barrier function Interleukin 4 Cupressuflavone lsoscutellarein-7-O-beta-xylopyranoside