Lee, Eun Jung Nam, Gi-Hoon Lee, Na Kyeong Kih, Minwoo Koh, Eunee Kim, Yoon Kyoung Hong, Yeonsun Kim, Soyoun Park, Seung-Yoon Jeong, Cherlhyun Yang, Yoosoo Kim, In-San 2024-01-19T23:04:12Z 2024-01-19T23:04:12Z 2021-09-03 2018-03-08 0935-9648 https://pubs.kist.re.kr/handle/201004/121609 A growing appreciation of the relationship between the immune system and the tumorigenesis has led to the development of strategies aimed at "re-editing" the immune system to kill tumors. Here, a novel tactic is reported for overcoming the activation-energy threshold of the immunosuppressive tumor microenvironment and mediating the delivery and presentation of tumor neoantigens to the host's immune system. This nature-derived nanocage not only efficiently presents ligands that enhance cancer cell phagocytosis, but also delivers drugs that induce immunogenic cancer cell death. The designed nanocage-therapeutics induce the release of neoantigens and danger signals in dying tumor cells, and leads to enhancement of tumor cell phagocytosis and cross-priming of tumor specific T cells by neoantigen peptide-loaded antigen-presenting cells. Potent inhibition of tumor growth and complete eradication of tumors is observed through systemic tumor-specific T cell responses in tumor draining lymph nodes and the spleen and further, infiltration of CD8+ T cells into the tumor site. Remarkably, after removal of the primary tumor, all mice treated with this nanocage-therapeutics are protected against subsequent challenge with the same tumor cells, suggesting development of lasting, tumor-specific responses. This designed nanocage-therapeutics "awakens" the host's immune system and provokes a durable systemic immune response against cancer. English WILEY-V C H VERLAG GMBH SIRP-ALPHA COMBINATION IMMUNOTHERAPY HUMAN FERRITIN DRUG-DELIVERY TUMORS NANOPARTICLE THERAPY CD47 NEOANTIGENS MUTATIONS Nanocage-Therapeutics Prevailing Phagocytosis and Immunogenic Cell Death Awakens Immunity against Cancer Article 10.1002/adma.201705581 1 ADVANCED MATERIALS, v.30, no.10 ADVANCED MATERIALS 30 10 scie scopus 000426720400014 2-s2.0-85040684773 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article SIRP-ALPHA COMBINATION IMMUNOTHERAPY HUMAN FERRITIN DRUG-DELIVERY TUMORS NANOPARTICLE THERAPY CD47 NEOANTIGENS MUTATIONS CD47 blockade immunogenic cell death intrinsic anticancer vaccination nanocages therapeutics