Han, Sungmin Kim, Minkyung Kim, Hyungmin Shin, Hyunjoon Youn, Inchan 2024-01-19T23:04:54Z 2024-01-19T23:04:54Z 2021-09-03 2018-03 0301-5629 https://pubs.kist.re.kr/handle/201004/121647 Ultrasound (US) can be used to noninvasively stimulate brain activity. However, reproducible motor responses evoked by US are only elicited when the animal is in a light state of anesthesia. The present study investigated the effects of ketamine on US-induced motor responses and cortical neuronal activity. US was applied to the motor cortex of mice, and motor responses were evaluated based on robustness scores. Cortical neuronal activity was observed by fluorescence calcium imaging. US-induced motor responses were inhibited more than 20 min after ketamine injection, and US-triggered Ca2+ transients in cortical neurons were effectively blocked by ketamine. Our results indicate that ketamine suppresses US-triggered Ca2+ transients in cortical neurons and, therefore, inhibits US-induced motor responses in a deep anesthetic state. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved. English ELSEVIER SCIENCE INC NONINVASIVE BRAIN-STIMULATION FOCUSED ULTRASOUND TRANSCRANIAL ULTRASOUND HIPPOCAMPAL-NEURONS INHALED ANESTHETICS CA2+ OSCILLATIONS IN-VITRO PARAMETERS CURRENTS CORTEX KETAMINE INHIBITS ULTRASOUND STIMULATION-INDUCED NEUROMODULATION BY BLOCKING CORTICAL NEURON ACTIVITY Article 10.1016/j.ultrasmedbio.2017.11.008 1 ULTRASOUND IN MEDICINE AND BIOLOGY, v.44, no.3, pp.635 - 646 ULTRASOUND IN MEDICINE AND BIOLOGY 44 3 635 646 scie scopus 000425842800013 2-s2.0-85038828919 Acoustics Radiology, Nuclear Medicine & Medical Imaging Acoustics Radiology, Nuclear Medicine & Medical Imaging Article NONINVASIVE BRAIN-STIMULATION FOCUSED ULTRASOUND TRANSCRANIAL ULTRASOUND HIPPOCAMPAL-NEURONS INHALED ANESTHETICS CA2+ OSCILLATIONS IN-VITRO PARAMETERS CURRENTS CORTEX Ultrasound stimulation Neuromodulation Ketamine Cortical neuron