Park, Jin-Soo Kwon, Hak Cheol 2024-01-19T23:30:28Z 2024-01-19T23:30:28Z 2021-09-03 2018-03 1660-3397 https://pubs.kist.re.kr/handle/201004/121666 A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivatives (1 and 2) comprised of naphthoquinone and geranyl moieties along with the known terpenoid, debromomarinone. The two-dimensional structure of these compounds was determined through spectral data analysis using data from NMR, MS and UV spectroscopy. Furthermore, the full structures of 1 and 2 including absolute configurations were unequivocally established by a combination of NMR experiments and chemical modifications. English MDPI HETEROLOGOUS EXPRESSION GENE-CLUSTER PRENYLATION NAPHTHABLIN METABOLITE BACTERIUM COMPOUND New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp CNQ-509 Article 10.3390/md16030090 1 MARINE DRUGS, v.16, no.3 MARINE DRUGS 16 3 scie scopus 000428510200016 2-s2.0-85044420620 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article HETEROLOGOUS EXPRESSION GENE-CLUSTER PRENYLATION NAPHTHABLIN METABOLITE BACTERIUM COMPOUND marine Actinobacteria natural product hybrid terpenoid meroterpenoid