Kang, Ji-Seon Hwang, Yune-Sahng Kim, Lark Kyun Lee, Sujung Lee, Wook-Bin Kim-Ha, Jeongsil Kim, Young-Joon 2024-01-19T23:30:34Z 2024-01-19T23:30:34Z 2021-09-03 2018-03 1016-8478 https://pubs.kist.re.kr/handle/201004/121672 Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, causes a severe defect in termination of type I interferon production. To further investigate the antiviral activity of OASL1, we examined its subcellular localization and regulatory roles in IFN production in the early and late stages of viral infection. We found OASL1, but not OASL2, formed stress granules trapping viral RNAs and promoted efficient RLR signaling in early stages of infection. Stress granule formation was dependent on RNA binding activity of OASL1. But in the late stages of infection, OASL1 interacted with IRF7 transcripts to inhibit translation resulting in down regulation of IFN production. These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections. English KOREAN SOC MOLECULAR & CELLULAR BIOLOGY I INTERFERON MDA5 RECOGNITION LOCALIZATION COMPLEXES APOPTOSIS VIRUSES PROTEIN IRF7 OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses Article 10.14348/molcells.2018.2293 1 MOLECULES AND CELLS, v.41, no.3, pp.214 - 223 MOLECULES AND CELLS 41 3 214 223 scie scopus kci 000434129100007 2-s2.0-85052795201 Biochemistry & Molecular Biology Cell Biology Biochemistry & Molecular Biology Cell Biology Article I INTERFERON MDA5 RECOGNITION LOCALIZATION COMPLEXES APOPTOSIS VIRUSES PROTEIN IRF7 anti-viral response OASL1 stress granule type I interferon