Han, Sungmin Lee, Jee Youn Heo, Eun Young Kwon, Il Keun Yune, Tae Young Youn, Inchan 2024-01-19T23:31:15Z 2024-01-19T23:31:15Z 2021-09-03 2018-02-12 0006-291X https://pubs.kist.re.kr/handle/201004/121704 An agarose scaffold can be useful for supporting and guiding injured axons after spinal cord injury (SCI), but the electrophysiological signal of regenerated axon in scaffolds has not yet been determined. The current study investigated whether a Matrigel-loaded agarose scaffold would enhance the regeneration of axons after SCI. Moreover, the functional connectivity of regenerated axons within the channels of the scaffold was evaluated by directly recording motor evoked potentials. Our data showed that the agarose scaffold containing Matrigel can support and enhance linearly organized axon regeneration after SCI. Additionally, motor evoked potenti.ils were successfully recorded from regenerated axons. These results demonstrate that an agarose scaffold loaded with Matrigel could promote the regeneration of axons and guide the reconnection of functional axons after SCI. (C) 2018 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE BRAIN-STIMULATION ULTRASOUND NEUROMODULATION SUPPORT SITES Implantation of a Matrigel-loaded agarose scaffold promotes functional regeneration of axons after spinal cord injury in rat Article 10.1016/j.bbrc.2018.01.157 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.496, no.3, pp.785 - 791 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 496 3 785 791 scie scopus 000426533500001 2-s2.0-85041204439 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article BRAIN-STIMULATION ULTRASOUND NEUROMODULATION SUPPORT SITES Spinal cord injury Corticospinal tract Agarose scaffold Functional connectivity Regeneration