Jung, Yujung Kim, Jin-Chul Park, No-June Bong, Sim-Kyu Lee, Sullim Legal, Hyun Jin, Li Tai Kim, Sang Moo Kim, Yong Kee Kim, Su-Nam 2024-01-19T23:31:26Z 2024-01-19T23:31:26Z 2022-01-10 2018-02-05 0006-291X https://pubs.kist.re.kr/handle/201004/121714 Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in a keratinocyte cell line and acts as an agonist of PPAR alpha. PPAR alpha agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. In this study, we confirmed that the effects of eupatilin improved AD-like symptoms in an oxazolone-induced AD-like mouse model. Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor alpha (TNF alpha), interferon-gamma (IFN-gamma), IL-1 beta, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model. Taken together, our data suggest that eupatilin is a potential candidate for the treatment of AD. (C) 2018 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE THYMIC STROMAL LYMPHOPOIETIN MAST-CELLS EPIDERMAL-KERATINOCYTES ALLERGIC INFLAMMATION IN-VIVO EXPRESSION SKIN TRANSCRIPTION CYTOKINE DIFFERENTIATION Eupatilin, an activator of PPAR alpha, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice Article 10.1016/j.bbrc.2018.01.098 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.496, no.2, pp.508 - 514 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 496 2 508 514 scie scopus 000424313500040 2-s2.0-85040611174 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article THYMIC STROMAL LYMPHOPOIETIN MAST-CELLS EPIDERMAL-KERATINOCYTES ALLERGIC INFLAMMATION IN-VIVO EXPRESSION SKIN TRANSCRIPTION CYTOKINE DIFFERENTIATION Eupatilin PPAR alpha Atopic dermatitis IL-4