Jegal, Jonghwan Park, No-June Park, Sang-a Bong, Sim-Kyu Jegal, Hyun Kim, Su-Nam Yang, Min Hye 2024-01-19T23:31:51Z 2024-01-19T23:31:51Z 2021-09-03 2018-02 0918-6158 https://pubs.kist.re.kr/handle/201004/121738 Juniperus chinensis, commonly Chinese juniper, has been used for treating inflammatory diseases. This study aimed to investigate anti-atopic dermatitis (AD) effects of standardized J. chinensis fruits extract on murine oxazolone- and 2,4-dinitrochlorobenzene (DNCB)-induced models of AD. Ear swelling, epidermis thickening, and eosinophils infiltration in the oxazolone-mediated dermatitis of BALB/c mice were significantly reduced upon topical application of J. chinensis fruits 95% EtOH extract (JCE). Besides, transdermal administration of JCE to SKIT -1 hairless mice inhibited the development of DNCB-induced AD -like skin lesions by suppressing transepidermal water loss and improving skin hydration. Decreased total serum immunoglobulin E (IgE) and interleukin (IL) -4 levels could be observed in atopic dorsal skin samples of JCE-treated group. According to the phytochemical analysis, JCE was found to contain isoscutellarein-7-O-beta-D-xyloside, cupressuflavone, and amentoflavone as main compounds. Therapeutic attempts with the J. chinensis fruits might be useful in the treatment of AD and related skin inflammatory diseases. English PHARMACEUTICAL SOC JAPAN SKIN BARRIER CONTACT HYPERSENSITIVITY NATURAL-PRODUCTS DRUG DISCOVERY HAIRLESS MOUSE CHILDREN BERRIES EXTRACT DISEASE LEAVES Juniperus chinensis Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice Article 10.1248/bpb.b17-00818 1 BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.41, no.2, pp.259 - 265 BIOLOGICAL & PHARMACEUTICAL BULLETIN 41 2 259 265 scie scopus 000424063900015 2-s2.0-85041486212 Pharmacology & Pharmacy Pharmacology & Pharmacy Article SKIN BARRIER CONTACT HYPERSENSITIVITY NATURAL-PRODUCTS DRUG DISCOVERY HAIRLESS MOUSE CHILDREN BERRIES EXTRACT DISEASE LEAVES Juniperus chinensis fruit atopic dermatitis transepidermal water loss skin hydration interleukin 4 immunoglobulin E