Jeon, Seongbeom Subbiah, Ramesh Bonaedy, Taufik Van, Seyoung Park, Kwideok Yun, Kyusik 2024-01-19T23:31:54Z 2024-01-19T23:31:54Z 2021-09-03 2018-02 0021-9541 https://pubs.kist.re.kr/handle/201004/121741 Magnetic nanoparticles (MNPs) are used as contrast agents and targeted drug delivery systems (TDDS) due to their favorable size, surface charge, and magnetic properties. Unfortunately, the toxicity associated with MNPs limits their biological applications. Surface functionalization of MNPs with selective polymers alters the surface chemistry to impart better biocompatibility. We report the preparation of surface functionalized MNPs using iron oxide NPs (MNPs), poly (lactic-co-glycolic acid) (PLGA), and sodium alginate via co-precipitation, emulsification, and electro-spraying, respectively. The NPs are in the nanosize range and negatively charged. Morphological and structural analyses affirm the surface functionalized nanostructure of the NPs. The surface functionalized MNPs are biocompatible, and demonstrate enhanced intracellular delivery under an applied magnetic field (H), which evinces the targeting ability of MNPs. After NP treatment, the physico-mechanical properties of fibroblasts are decided by the selective MNP uptake under on or off magnetic field conditions. We envision potential use of biocompatible surface functionalized MNP for intracellular-, targeted-DDS, imaging, and for investigating cellular mechanics. English WILEY IRON-OXIDE NANOPARTICLES EXTRACELLULAR-MATRIX DRUG-DELIVERY QUANTUM DOTS FATE DIFFERENTIATION HYPERTHERMIA HYDROGELS RELEASE Surface functionalized magnetic nanoparticles shift cell behavior with on/off magnetic fields Article 10.1002/jcp.25980 1 JOURNAL OF CELLULAR PHYSIOLOGY, v.233, no.2, pp.1168 - 1178 JOURNAL OF CELLULAR PHYSIOLOGY 233 2 1168 1178 scie scopus 000414593500040 2-s2.0-85020213953 Cell Biology Physiology Cell Biology Physiology Article IRON-OXIDE NANOPARTICLES EXTRACELLULAR-MATRIX DRUG-DELIVERY QUANTUM DOTS FATE DIFFERENTIATION HYPERTHERMIA HYDROGELS RELEASE atomic force microscopy cell stiffness cytotoxicity interface magentic nanoparticles