Kim, Sung Jong Lee, Seung-Woo Song, Jin Dong Kwon, Young-Wan Lee, Kyung-Jin Koo, Hyun Cheol 2024-01-19T23:32:17Z 2024-01-19T23:32:17Z 2021-09-03 2018-02 0925-4005 https://pubs.kist.re.kr/handle/201004/121763 A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor. (C) 2017 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE SA IRON-OXIDE NANOPARTICLES SERUM ALPHA-FETOPROTEIN SUPERPARAMAGNETIC NANOPARTICLES HEPATOCELLULAR-CARCINOMA IMMUNOASSAY HEPATITIS SENSORS DESIGN MRI An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles Article 10.1016/j.snb.2017.09.108 1 SENSORS AND ACTUATORS B-CHEMICAL, v.255, pp.2894 - 2899 SENSORS AND ACTUATORS B-CHEMICAL 255 2894 2899 scie scopus 000414686500054 2-s2.0-85030480524 Chemistry, Analytical Electrochemistry Instruments & Instrumentation Chemistry Electrochemistry Instruments & Instrumentation Article IRON-OXIDE NANOPARTICLES SERUM ALPHA-FETOPROTEIN SUPERPARAMAGNETIC NANOPARTICLES HEPATOCELLULAR-CARCINOMA IMMUNOASSAY HEPATITIS SENSORS DESIGN MRI Biosensor Magnetoresistive sensor Nanoparticle InSb Antigen-antibody reaction