Jo, Hanbyeol Hassan, Ahmed H. E. Jung, Seung Young Lee, Jae Kyun Cho, Yong Seo Min, Sun-Joon 2024-01-19T23:32:19Z 2024-01-19T23:32:19Z 2021-09-03 2018-02 1523-7060 https://pubs.kist.re.kr/handle/201004/121765 A concise synthesis of 8-azabicyclo [3.2.1] octanes via sequential oxidative Mannich reactions is described. This approach involves an intermolecular oxidative Mannich coupling reaction between N-aryl pyrrolidines with TMS enol ether and a subsequent intramolecular oxidative Mannich cyclization of the corresponding silyl enol ether. DDQ is used as a key oxidant for both reactions. English AMER CHEMICAL SOC Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines Article 10.1021/acs.orglett.8b00098 1 ORGANIC LETTERS, v.20, no.4, pp.1175 - 1178 ORGANIC LETTERS 20 4 1175 1178 N scie scopus 000426013600070 2-s2.0-85042177036 Chemistry, Organic Chemistry Article CATALYTIC ENANTIOSELECTIVE SYNTHESIS DEHYDROGENATIVE COUPLING REACTIONS TROPANE ALKALOIDS C-C ASYMMETRIC-SYNTHESIS BOND FORMATION FUNCTIONALIZED TROPANES PHOTOREDOX AMINES DERIVATIVES Mannich reactions 8-azabicyclo[3.2.1]octanes. Silyl Enol Ethers