Seo, Bo-Bae Chang, Hae-Im Choi, Hyuck Koh, Jeong-Tae Yun, Kwi-Dug Lee, Jae-Yeol Song, Soo-Chang 2024-01-19T23:32:32Z 2024-01-19T23:32:32Z 2021-09-03 2018-02 1552-4973 https://pubs.kist.re.kr/handle/201004/121778 An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created on both sides of the mandibular bone. Next, two implants were transplanted into each defect. In situ gelling polymer solutions with or without BMP-2 were applied to cover the implants and mandibular defects. The effects of the in situ gelling and sustained BMP-2 releasing (IGSR) hydrogel system on peri-implant bone regeneration were evaluated by radiologic examination, micro-computed tomography, and histomorphometric analysis. Twelve weeks after the treatment, significant bone generation at the peri-implant site occurred following BMP-2/IGSR hydrogel treatment. Bone volume and mineral density were increased by 1.7- and 1.3-fold, respectively (p<0.01 and 0.05 vs. control, respectively) for the BMP-2/IGSR hydrogel system. And, 0.57-0.31 mm vertical bone generation was observed at the peri-implant site for the BMP-2/IGSR hydrogel system, while rare vertical bone generation occurred in the control group. The BMP-2/IGSR hydrogel system significantly increased bone to implant contact % between induced bone and existing bone (p<0.05 and 0.01 vs. control). These vertical bone regeneration and higher osseointegration levels demonstrated the effectiveness of the BMP-2/IGSR hydrogel system. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 751-759, 2018. English WILEY MORPHOGENETIC PROTEIN-2 DELIVERY RHBMP-2 OSSEOINTEGRATION AUGMENTATION COMBINATION CELLS New approach for vertical bone regeneration using in situ gelling and sustained BMP-2 releasing poly(phosphazene) hydrogel system on peri-implant site with critical defect in a canine model Article 10.1002/jbm.b.33885 1 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v.106, no.2, pp.751 - 759 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 106 2 751 759 scie scopus 000419374000028 2-s2.0-85017362766 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article MORPHOGENETIC PROTEIN-2 DELIVERY RHBMP-2 OSSEOINTEGRATION AUGMENTATION COMBINATION CELLS in situ forming hydrogel biodegradable hydrogel bone morphogenetic protein-2 (BMP-2) ossointegration vertical bone regeneration