Choi, Y. Ha, S. Lee, Y.-S. Kim, Y.K. Lee, D.S. Kim, D.J. 2024-01-19T23:32:35Z 2024-01-19T23:32:35Z 2021-09-02 2018-02 1869-3474 https://pubs.kist.re.kr/handle/201004/121781 The pathological features of Alzheimer’s disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer’s disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer’s disease. ？ 2017, Korean Society of Nuclear Medicine. English Springer Verlag Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies Article 10.1007/s13139-017-0484-7 1 Nuclear Medicine and Molecular Imaging, v.52, no.1, pp.24 - 30 Nuclear Medicine and Molecular Imaging 52 1 24 30 N scopus kci ART002315569 2-s2.0-85040942047 Review amyloid beta protein radioligand radiopharmaceutical agent tau protein Alzheimer disease chromosome 17 chronic traumatic encephalopathy cognition corticobasal degeneration degenerative disease disease exacerbation frontotemporal dementia human neurofibrillary tangle parkinsonism positron emission tomography priority journal progressive supranuclear palsy Review senile plaque tauopathy Alzheimer’s disease Imaging ligands Pet Radiopharmaceutical Tau Tauopathy