Lee, Seung Hyun Kim, Jeongjin Shin, Jung Ho Lee, Han Eol Kang, Il-Suk Gwak, Kiuk Kim, Dae-Shik Kim, Daesoo Lee, Keon Jae 2024-01-19T23:32:38Z 2024-01-19T23:32:38Z 2021-08-31 2018-02 2211-2855 https://pubs.kist.re.kr/handle/201004/121783 The microstimulation of specific neural populations of the brain is one of the facile and reliable methods used in neuroscience for deduction of functional movement, complex behavior and even long-range connectivity. Recent advanced biomedical tools now employ flexible optoelectronic devices combined with optogenetic mouse models to induce high spatiotemporal modulation of specific brain activity. However, most current applications are limited to activation of small functional regions using blue-light driven channelrhodopsin. In this report, we introduce flexible AlGaInP vertical light-emitting diodes (VLEDs) for perturbation of specific functional areas of mouse cortex. Micro-scaled LEDs effectively compress the conductive balls dispersed in anisotropic conductive film (ACF) resulting red light emissions with high optical power density, capable of stimulating motor neurons deep below layer III from the brain surface. Selective operation of pulsed red light from f-VLEDs induces mouse body movements and synchronized electromyogram (EMG) signals. The expression of chrimson, red-shifted channelrhodopsin, enables red-light excitation of targeted functional area of motor cortex. This demonstration opens new opportunities for entire cortical mapping, to explore the connectivity between undefined motor areas in the mouse brain. English ELSEVIER FREELY MOVING MICE TOP-DOWN CONTROL MOTOR CORTEX IN-VIVO STIMULATION MEMORY NEURONS ARRAYS Optogenetic control of body movements via flexible vertical light-emitting diodes on brain surface Article 10.1016/j.nanoen.2017.12.011 1 NANO ENERGY, v.44, pp.447 - 455 NANO ENERGY 44 447 455 scie scopus 000419833900051 2-s2.0-85038847352 Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Chemistry Science & Technology - Other Topics Materials Science Physics Article FREELY MOVING MICE TOP-DOWN CONTROL MOTOR CORTEX IN-VIVO STIMULATION MEMORY NEURONS ARRAYS Light-emitting diode Anisotropic conductive film Optogenetics Motor cortex Flexible optoelectronics