Ha, Min Woo Lee, Jun Young Kim, Doyoung Lee, Geumwoo Lee, Jae Kyun Hong, Suckchang Park, Hyeung-geun 2024-01-19T23:33:03Z 2024-01-19T23:33:03Z 2021-09-03 2018-01-19 0022-3263 https://pubs.kist.re.kr/handle/201004/121801 An efficient synthetic method for establishing chiral alpha-thio-alpha-quaternary stereogenic center was successfully developed. The enantioselective a-alkylation of alpha-acylthiomalonates under phase-transfer catalytic conditions [50% aq. KOH, toluene, 20 degrees C, and (S,S)-3,4,5-trifluorophenyl-NAS bromide] provided the corresponding alpha-acylthio-alpha-alkylmalonates in high chemical yields (up to 99%) and high optical yields (up to 98% ee). English AMER CHEMICAL SOC PRACTICAL ASYMMETRIC-SYNTHESIS AMINO SULFENYLATION CONSTRUCTION ARYLATION ACIDS Enantioselective Synthesis of Chiral alpha-Thio-Quaternary Stereogenic Centers via Phase-Transfer-Catalyzed alpha-Alkylation of alpha-Acylthiomalonates Article 10.1021/acs.joc.7b02605 1 JOURNAL OF ORGANIC CHEMISTRY, v.83, no.2, pp.1011 - 1018 JOURNAL OF ORGANIC CHEMISTRY 83 2 1011 1018 scie scopus 000423252300045 2-s2.0-85040807884 Chemistry, Organic Chemistry Article PRACTICAL ASYMMETRIC-SYNTHESIS AMINO SULFENYLATION CONSTRUCTION ARYLATION ACIDS best-selling drugs X-ray crystallographic structure Enantioselective Synthesis α-Alkylation of α-Acylthiomalonates