Cha, Kyu-Min Kopalli, Spandana Rajendra Han, Sang Yun Lee, Sang-Ho Jeong, Min-Sik Cho, Jae Youl Han, Chang-Gyun Lee, Seung-Ho Kim, Soo-Nam Kim, Jin-Chul Kim, Si-Kwan 2024-01-19T23:34:07Z 2024-01-19T23:34:07Z 2021-09-03 2018-01 1756-4646 https://pubs.kist.re.kr/handle/201004/121860 The effect of Korean red ginseng (KRG; Panax ginseng Meyer) against doxorubicin (DOX)-induced testicular inflammation was investigated. Male Sprague-Dawley rats were treated with DOX (1 mg mL(-1) kg(-1) week(-1); intra-peritoneally) for 8 weeks, and KRG water extract (EX1; 100 and EX2; 200 mg/kg/day; orally) was administered for 9 weeks starting one week before DOX exposure. The expression levels related to spermatogenesis, inflammatory and autophagy markers were evaluated using western blotting and reverse transcriptase polymerase chain reaction. DOX-induced a significant (p < .05) alteration in the expression of antioxidation spermatogenesis and sex hormone receptors genes when compared with control groups, which were attenuated with KRG-WE treatment significantly (p < .05 similar to p < .01). KRG-WE also ameliorated the DOX-induced alteration in pro-inflammatory cytokines via the mitogen-activated protein kinases/nuclear factor kappa-B pathway and autophagy in the testes of rats. In conclusion, KRG might be used as a functional food for prevention of chemotherapy -induced testicular inflammation. English ELSEVIER SCIENCE BV TUMOR-NECROSIS-FACTOR NF-KAPPA-B PANAX-GINSENG AGED RATS HEART-FAILURE CANCER CELLS GUINEA-PIGS GINSENOSIDES STRESS INHIBITION Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses Article 10.1016/j.jff.2017.12.008 1 JOURNAL OF FUNCTIONAL FOODS, v.40, pp.736 - 743 JOURNAL OF FUNCTIONAL FOODS 40 736 743 scie scopus 000428005500080 2-s2.0-85037982474 Food Science & Technology Nutrition & Dietetics Food Science & Technology Nutrition & Dietetics Article TUMOR-NECROSIS-FACTOR NF-KAPPA-B PANAX-GINSENG AGED RATS HEART-FAILURE CANCER CELLS GUINEA-PIGS GINSENOSIDES STRESS INHIBITION Panax ginseng Oxidative stress Autophagy Spermatogenesis Cytokines Functional foods