Seo, Jungmok Shin, Jung-Youn Leijten, Jeroen Jeon, Oju Camci-Unal, Gulden Dikina, Anna D. Brinegar, Katelyn Ghaemmaghami, Amir M. Alsberg, Eben Khademhosseini, Ali 2024-01-19T23:34:19Z 2024-01-19T23:34:19Z 2021-09-03 2018-01 0142-9612 https://pubs.kist.re.kr/handle/201004/121871 The rapid development of new biomaterials and techniques to modify them challenge our capability to characterize them using conventional methods. In response, numerous high-throughput (HT) strategies are being developed to analyze biomaterials and their interactions with cells using combinatorial approaches. Moreover, these systematic analyses have the power to uncover effects of delivered soluble bioactive molecules on cell responses. In this review, we describe the recent developments in HT approaches that help identify cellular microenvironments affecting cell behaviors and highlight HT screening of biochemical libraries for gene delivery, drug discovery, and toxicological studies. We also discuss HT techniques for the analyses of cell secreted biomolecules and provide perspectives on the future utility of HT approaches in biomedical engineering. Published by Elsevier Ltd. English ELSEVIER SCI LTD MESENCHYMAL STEM-CELLS CARBOHYDRATE MICROARRAYS IN-VITRO ON-CHIP GENE-EXPRESSION OSTEOGENIC DIFFERENTIATION COMBINATORIAL DEVELOPMENT MICROFLUIDIC PLATFORM BIOMATERIALS CANCER High-throughput approaches for screening and analysis of cell behaviors Article 10.1016/j.biomaterials.2017.06.022 1 BIOMATERIALS, v.153, pp.85 - 101 BIOMATERIALS 153 85 101 scie scopus 000418223800007 2-s2.0-85030687869 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Review MESENCHYMAL STEM-CELLS CARBOHYDRATE MICROARRAYS IN-VITRO ON-CHIP GENE-EXPRESSION OSTEOGENIC DIFFERENTIATION COMBINATORIAL DEVELOPMENT MICROFLUIDIC PLATFORM BIOMATERIALS CANCER High-throughput system Cell-biomaterial interactions Cellular microenvironments Biomolecule delivery Biomaterial screening High-throughput biosensor