Chun, Heejung Lee, C. Justin 2024-01-19T23:34:30Z 2024-01-19T23:34:30Z 2021-09-03 2018-01 0168-0102 https://pubs.kist.re.kr/handle/201004/121881 Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons from unsuccessful neuron-focused research for an AD cure, non-cell autonomous mechanisms including brain inflammation and reactive astrocytes have recently been in the spotlight as potential therapeutic targets for AD. Studies have shown that reactive astrocytes are not only the result of inflammatory defense reactions, but also an active catabolic decomposer that acts by taking up amyloid beta toxins. Here, we give an overview of the characteristics of reactive astrocytes as pathological features of AD. Reactive astrocytes exert biphasic effects, that is, beneficial or detrimental depending on multiple factors. Many efforts have been put forth for defining and characterizing molecular signatures for the beneficial and detrimental reactive astrocytes. In the foreseeable future, manipulating and targeting each established molecular signature should have profound therapeutic implications for the treatment of AD. (c) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved. English ELSEVIER IRELAND LTD NECROSIS-FACTOR-ALPHA MILD COGNITIVE IMPAIRMENT MONOAMINE OXIDASE-B AMYLOID-BETA NITRIC-OXIDE GLUTAMATE RELEASE OXIDATIVE STRESS MOUSE MODEL COMPOUND B VITAMIN-E Reactive astrocytes in Alzheimer's disease: A double-edged sword Article 10.1016/j.neures.2017.11.012 1 NEUROSCIENCE RESEARCH, v.126, pp.44 - 52 NEUROSCIENCE RESEARCH 126 44 52 scie scopus 000418893300008 2-s2.0-85037735178 Neurosciences Neurosciences & Neurology Review NECROSIS-FACTOR-ALPHA MILD COGNITIVE IMPAIRMENT MONOAMINE OXIDASE-B AMYLOID-BETA NITRIC-OXIDE GLUTAMATE RELEASE OXIDATIVE STRESS MOUSE MODEL COMPOUND B VITAMIN-E Reactive astrocytes Alzheimer&apos s disease Brain inflammation