Cho, Chang-Hoon Hwang, Eun Mi Park, Jae-Yong 2024-01-19T23:34:32Z 2024-01-19T23:34:32Z 2021-09-03 2018-01 1661-6596 https://pubs.kist.re.kr/handle/201004/121883 Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIKtandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain. English MDPI DOMAIN POTASSIUM CHANNEL RECTIFYING K+ CHANNEL FUNCTIONAL HETERODIMERS NEURONAL EXCITABILITY SUMOYLATION SILENCES PASSIVE CONDUCTANCE TASK-3 KCNK9 SUBUNITS TREK-1 ASTROCYTES Emerging Roles of TWIK-1 Heterodimerization in the Brain Article 10.3390/ijms19010051 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 1 scie scopus 000424407200049 2-s2.0-85039067290 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review DOMAIN POTASSIUM CHANNEL RECTIFYING K+ CHANNEL FUNCTIONAL HETERODIMERS NEURONAL EXCITABILITY SUMOYLATION SILENCES PASSIVE CONDUCTANCE TASK-3 KCNK9 SUBUNITS TREK-1 ASTROCYTES TWIK-1 K2P astrocyte brain heterodimerization