Kim, Anne Claire Lim, Sungsu Kim, Yun Kyung 2024-01-19T23:34:33Z 2024-01-19T23:34:33Z 2021-09-03 2018-01 1661-6596 https://pubs.kist.re.kr/handle/201004/121884 Amyloid and tau aggregation are implicated in manifold neurodegenerative diseases and serve as two signature pathological hallmarks in Alzheimer's disease (AD). Though aging is considered as a prominent risk factor for AD pathogenesis, substantial evidence suggests that an imbalance of essential biometal ions in the body and exposure to certain metal ions in the environment can potentially induce alterations to AD pathology. Despite their physiological importance in various intracellular processes, biometal ions, when present in excessive or deficient amounts, can serve as a mediating factor for neurotoxicity. Recent studies have also demonstrated the contribution of metal ions found in the environment on mediating AD pathogenesis. In this regard, the neuropathological features associated with biometal ion dyshomeostasis and environmental metal ion exposure have prompted widespread interest by multiple research groups. In this review, we discuss and elaborate on findings from previous studies detailing the possible role of both endogenous and exogenous metal ions specifically on amyloid and tau pathology in AD. English Multidisciplinary Digital Publishing Institute (MDPI) Metal Ion Effects on A and Tau Aggregation Article 10.3390/ijms19010128 1 International Journal of Molecular Sciences, v.19, no.1 International Journal of Molecular Sciences 19 1 Y scie scopus 000424407200125 2-s2.0-85040035859 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review AMYLOID-PRECURSOR-PROTEIN ALZHEIMERS-DISEASE A-BETA OXIDATIVE STRESS NEUROFIBRILLARY TANGLES HYPERPHOSPHORYLATED-TAU CEREBRAL-CORTEX BRAIN-REGIONS RAT-BRAIN PHOSPHORYLATION metal tau -amyloid