Lim, Won-Chul Kim, Hyunhee Kim, Young-Joo Park, Seung-Ho Song, Ji-Hye Lee, Ki Heon Lee, In Ho Lee, Yoo-Kyung So, Kyeong A. Choi, Kyung-Chul Ko, Hyeonseok 2024-01-20T00:01:05Z 2024-01-20T00:01:05Z 2021-09-03 2017-12-01 0960-894X https://pubs.kist.re.kr/handle/201004/121943 Brain-derived neurotrophic factor (BDNF), the TrkB ligand, is associated with aggressive malignant behavior, including migration and invasion, in tumor cells and a poor prognosis in patients with various types of cancer. Delphinidin is a diphenylpropane-based polyphenolic ring structure-harboring compound, which exhibits a wide range of pharmacological activities, anti-tumor, anti-oxidant, anti-inflammatory, anti-angiogenic and anti-mutagenic activity. However, the possible role of delphinidin in the cancer migration and invasion is unclear. We investigated the suppressive effect of delphinidin on the cancer migration and invasion. Thus, we found that BDNF enhanced cancer migration and invasion in SKOV3 ovarian cancer cell. To exam the inhibitory role of delphinidin in SKOV3 ovarian cancer migration and invasion, we investigated the use of delphinidin as inhibitors of BDNF-induced motility and invasiveness in SKOV3 ovarian cancer cells in vitro. Here, we found that delphinidin prominently inhibited the BDNF-induced increase in cell migration and invasion of SKOV3 ovarian cancer cells. Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9. Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-kappa B permitted by the BDNF in SKOV3 ovarian cancer cells. Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation. (C) 2017 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. EPITHELIAL-MESENCHYMAL TRANSITION A549 LUNG-CANCER MOLECULAR-MECHANISMS DOWN-REGULATION HEPATOCELLULAR-CARCINOMA NEUROBLASTOMA-CELLS ANOIKIS RESISTANCE SIGNALING PATHWAY INDUCED APOPTOSIS HCT116 CELLS Delphinidin inhibits BDNF-induced migration and invasion in SKOV3 ovarian cancer cells Article 10.1016/j.bmcl.2017.09.024 1 Bioorganic & Medicinal Chemistry Letters, v.27, no.23, pp.5337 - 5343 Bioorganic & Medicinal Chemistry Letters 27 23 5337 5343 scie scopus 000415643400045 2-s2.0-85033234115 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article EPITHELIAL-MESENCHYMAL TRANSITION A549 LUNG-CANCER MOLECULAR-MECHANISMS DOWN-REGULATION HEPATOCELLULAR-CARCINOMA NEUROBLASTOMA-CELLS ANOIKIS RESISTANCE SIGNALING PATHWAY INDUCED APOPTOSIS HCT116 CELLS Delphinidin Brain-derived neurotrophic factor (BDNF) Akt Ovarian cancer Migration Invasion