Han, Tae-Su Hur, Keun Choi, Boram Lee, Ji-Yeon Byeon, Sun-Ju Min, Jimin Yu, Jieun Cho, Jung-Kyo Hong, Jimin Lee, Hyuk-Joon Kong, Seong-Ho Kim, Woo-Ho Yanagihara, Kazuyoshi Song, Soo-Chang Yang, Han-Kwang 2024-01-20T00:01:19Z 2024-01-20T00:01:19Z 2022-01-25 2017-12 1949-2553 https://pubs.kist.re.kr/handle/201004/121956 Peritoneal carcinomatosis (PC) of gastric origin has a poor prognosis with short survival due to lack of effective therapeutic modalities. Here, we evaluated the therapeutic efficacy of an injectable thermosensitive poly (organophosphazene) (PPZ) hydrogel with docetaxel (DTX-gel) to develop an effective therapeutic agent for patient with PC. Three days after inoculation of highly metastatic 44As3Luc cells into peritoneal cavity, the mice were intravenously or intraperitoneally administered with docetaxel alone (DTX-sol IV or IP), and intraperitoneally injected with DTX-gel. The anti-tumor activity was monitored by bioluminescence live imaging system. Compared to DTX-sol IV or IP, the tumor growth was significantly reduced in the DTX-gel treated mice (p<0.0001, p=0.0001). Furthermore, the survival rate was significantly increased in the DTX-gel treated mice compared to DTX-sol IV or IP treated mice (p<0.0001, p=0.0068). Our results demonstrated that DTX-gel suppresses peritoneal metastasis by continuing release of chemotherapy agent, which leads to increase the survival rate in a PC model. Therefore, biodegradable thermosensitive hydrogel with docetaxel system can be a good anti-cancer agent for PC. English IMPACT JOURNALS LLC Improvement of anti-cancer drug efficacy via thermosensitive hydrogel in peritoneal carcinomatosis in gastric cancer Article 10.18632/oncotarget.22312 1 ONCOTARGET, v.8, no.65, pp.108848 - 108858 ONCOTARGET 8 65 108848 108858 N scie scopus 000419565400045 2-s2.0-85037700781 Oncology Cell Biology Oncology Cell Biology Article LIPID IMPLANT SYSTEM OVARIAN-CANCER LOCALIZED DELIVERY IN-VITRO PACLITAXEL DOCETAXEL CHITOSAN DISSEMINATION MICROSPHERES CHEMOTHERAPY gastric cancer peritoneal carcinomatosis PPZ hydrogel docetaxel live imaging