Elnaggar, Mahmoud A. Subbiah, Ramesh Han, Dong Keun Joung, Yoon Ki 2024-01-20T00:01:30Z 2024-01-20T00:01:30Z 2021-09-04 2017-12 1742-5247 https://pubs.kist.re.kr/handle/201004/121966 Introduction: Nitric oxide (NO) is crucial for body homeostasis at moderate levels, but cytotoxic at high levels, thus making it a potential candidate for anticancer therapies and antibacterial surface coatings. To date, NO use has been limited due to its very short half-life. Many strategies have been utilized in an attempt to control the half-life of NO, including (but not limited to) lipid-based carriers, due to their biocompatibility and versatility. Areas covered: In this review, we discuss the latest studies that aimed to control the release of NO via a variety of lipid-based delivery carriers, such as liposomes (echogenic and normal) and microbubbles. In addition, we discuss the different types of NO donors used to control and target the release of NO. Expert opinion: Achieving a NO releasing lipid-based systems to mimic the natural release rate of NO remains a challenging task. Many promising strategies are still to be tackled, such as NO release supported lipid bilayers using GPx mimicking catalysts instead of vesicles, or the use of lipophillic NO donors such as nitrooleate instead of the conventional hydrophilic NO donors. These new strategies may present us with better alternatives to the previously published systems. English Ashley Publications Ltd. Lipid-based carriers for controlled delivery of nitric oxide Article 10.1080/17425247.2017.1285904 1 Expert Opinion on Drug Delivery, v.14, no.12, pp.1341 - 1353 Expert Opinion on Drug Delivery 14 12 1341 1353 N scie scopus 000415660200001 2-s2.0-85018389753 Pharmacology & Pharmacy Pharmacology & Pharmacy Review STABILIZED MULTILAYERED LIPOSOMES PHTHALOCYANINE RUTHENIUM COMPLEX PULMONARY ARTERIAL-HYPERTENSION LOADED ECHOGENIC LIPOSOMES THERAPEUTIC GAS DELIVERY COLON-CANCER CELLS IN-VITRO OXYGEN DELIVERY RELAXING FACTOR STAPHYLOCOCCUS-AUREUS Nitric oxide liposomes echogenic liposomes microbubbles supported lipid bilayer nitric oxide donors